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Despite their diverse pharmacological properties, these drugs converge on shared neurotoxic pathways, including oxidative stress, mitochondrial dysfunction, excitotoxicity, and neuroinflammation
Covalent or non-covalent inhibitors are again attracting attention, and they target site-specifically a cysteine residue near the active pocket of druggable proteins
Budget-conscious approach: CMP ($15-25 covers liver, kidney, electrolytes) CBC ($10-20) Lipid panel ($15-30) Morning cortisol ($20-40) Home blood pressure monitor ($30-60, one-time purchase) Dermatological exam (check insurance coverage often covered as preventive) Putting It All Together: Sample Protocol Week -2 to -1 (Baseline): Run CMP, CBC, lipid panel, cortisol
Additionally, the antioxidants present in durian help protect the liver from free radical damage
Free tryptophan, i.e., the tryptophan that is not used for protein synthesis is mainly catabolized through the kynurenine pathway to produce a wide range of biologically active metabolites, collectively termed kynurenines
