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The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A
In 3-KO mice, these reductions were absent, reinforcing the idea that 3-AR plays a necessary role in regulating the response of brown adipose tissue to these agents [2]
Adipose triglyceride lipase is a key lipase for the mobilization of lipid droplets in human beta cells and critical for the maintenance of Syntaxin1a level in beta cells
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