After adjusting for baseline risk factors, GLP-1 users had significantly lower recurrence rates than those using SGLT2 inhibitors or DPP-4 inhibitors
Several GLP-1 agonists have FDA approval for other indications that may overlap with BED patient populations: Semaglutide (Wegovy) and liraglutide (Saxenda) are approved for chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity Semaglutide (Ozempic), liraglutide (Victoza), dulaglutide (Trulicity), and tirzepatide (Mounjaro) are approved for type 2 diabetes management Tirzepatide (Zepbound) is approved for chronic weight management When clinicians prescribe GLP-1 agonists for BED, this constitutes off-label use a legal and common practice in medicine when evidence suggests potential benefit and approved treatments are inadequate
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(Read more about tryptophan, kynurenine, serotonin, and genetics.) Allergies, COVID-19, and depression and anxiety: A study of the psychological impact of COVID-19 revealed that people with allergies, which chronically raise inflammatory cytokine levels, were more likely to have PTSD and depression after COVID-19.[ref] Another study found that people with systemically elevated inflammation after COVID-19 illness were at an increased risk of depression, anxiety, or PTSD.[ref] While there is a lot of swirl and science about long-haul COVID symptoms, previous research on other viruses that remain active or reactivate (e.g., Epstein-Barr virus, cytomegalovirus) also has links between infection, inflammatory cytokines, and depression.[ref] Inflammation, Depression, and Anxiety: Genotype Report Access this content: An active subscription is required to access this content

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Although these medications contain the same active ingredient, their approved indications and dosing differ based on formulation and strength