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Generally, our patients begin to experience weight loss within the first few weeks of initiating treatment

In the STEP 1 trial extension and other follow-up studies, patients who stopped semaglutide regained approximately two-thirds of their lost weight within a year of discontinuation

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Her lab has shown that GLP-1 signaling through serotonin neurons contributes to reduced food intake, and animal studies suggest broader effects on mood and emotionality