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In mice with diet induced obesity, dietary capsaicin supplementation or genetic activation of TRPV1 increases the number of UCP1 positive beige adipocytes in white adipose tissue and improves resistance to obesity

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Further evaluation of metabolic models of the microbiota by examining 70 metabolic pathways from the KEGG database revealed a significant increase in the function of glutamate-cysteine ligase and GSH biosynthesis in the metformin-modulated microbiota (Fig