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10.1111/j.1439-0531.2008.01290.x 69

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Unlike older therapies, which often worked regardless of blood sugar levels and carried a significant risk of hypoglycemia or weight gain, GLP-1s stimulate insulin release only when glucose levels are elevated and suppress inappropriate glucagon secretion

[9] [10] This multifaceted mechanism helps improve glycaemic control and can support weight reduction, as outlined in NICE guideline NG28 for type 2 diabetes management

Blood work timeline Get baseline blood work before starting tirzepatide: complete metabolic panel, HbA1c, fasting insulin, lipid panel, and thyroid function