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demonstrated that Angelica sinensis polysaccharide (ASP) treatment upregulated Adcy4 (involved in calcium signaling), Cldn5 and Myl9 (tight junction-associated), as well as Slit3 and Rgs18 (bone remodeling-related genes) (15)
doi: 10.1001/archneurol.2010.227 116 DreherSIGrubbaPvon ToerneCMoruzziAMaurerJGojTet al
If IGF-1 LR3 levels remain higher than normal for an extended period of time, issues with cardiac rhythm and heart valves may arise
With continuous use, it helps reveal a brighter, smoother, and more luminous complexion
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However, GH levels may gradually return to baseline over time
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