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Daniela Hurtado, an endocrinologist at the Mayo Clinic (as quoted in Kritz, 2025)

NAD + has been shown to be effective for a wide range of conditions including chronic fatique, cognative decline, depression, diabetes, fibromyalgia, heart disease, multiple sclerosis, Parkinsons disease, and others

By staying informed about the potential side effects, engaging in open communication, and employing strategies to mitigate these effects, patients and healthcare providers can navigate the complexities of treatment together, optimizing outcomes and enhancing overall well-being

At 48 weeks, average weight loss was 24.2%

Daily administration would produce accumulating plasma levels far beyond the studied range, dramatically increasing side effects without proportional benefit