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Ingredients Component Dose per Serving %DV Berberine HCl 500 mg * White Mulberry Leaf Extract 250 mg * AlphaLipoic Acid 200 mg * Chromium Picolinate 300 mcg * Black Pepper Fruit Extract 2 mg * Vegetable cellulose capsule * Magnesium stearate * Silicon dioxide * *Daily Value (DV) not established

lncRNA PICSAR alters cell proliferation, migration, invasion, IL-6, IL-8, and MMP-3 production through sponging miR-4701-5p, in other words, lncRNA PICSAR can competitively combine miR-4701-5p to affect downstream target genes (257)

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These functional assays show that both the mucosal (MAdCAM-1/alpha 4 beta 7) and the peripheral (PNAd/L-selectin) recognition systems are involved in this binding