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Done correctly, they push effective exclusivity 5-15 years past the molecule patent cliff
Levocarnitine and muscle metabolism in patients with end-stage renal disease
In vivo, in conscious swine a model with GH axis pharmacology closely reflective of human GH secretion ipamorelin produced an ED50 of 2.3 0.03 nmol/kg and an Emax of 65 0.2 ng GH/mL plasma, comparable to GHRP-6 (ED50 3.9 1.4 nmol/kg, Emax 74 7 ng/mL) but with substantially superior selectivity
This appeared to be true even after accounting for the drugs impact on weight loss
Cancer Res Treat (2017) 49(1):708
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