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These results are the basis for a positioning of the DPP-4 inhibitors as second-line therapy for the treatment of type 2 diabetes, especially, when hypoglycaemia should strictly be avoided (see section below)

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Orforglipron Improves Glucose Tolerance, Reduces Food Intake, and Lowers Adipose Tissue Weight in HFD-Induced Humanized GLP-1R Mice B-hGLP1R mice plus were fed a high-fat diet (HFD) to induce obesity, followed by Orforglipron treatment

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