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PIONEER 9 and PIONEER 10 are trials that enrolled Japanese participants with T2DM to meet regulatory requirements in Japan
Participants were randomly assigned to receive either weekly injections of tirzepatide or an non-acting placebo
Dietary supplements are nutritional supports that do not replace a balanced diet, a healthy lifestyle, and validated medical treatments
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The observation that the insulinotropic actions of GLP-1 are reduced in type 2 diabetes mellitus (T2DM) led to the development of incretin-based therapies GLP-1 receptor agonists and dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of hyperglycaemia in these patients
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