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(2018) 1:CD005195

Crohns & Colitis Foundation

Feed-forward signaling of TNF-alpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice

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The pharmacokinetic profile of tirzepatide supports once-weekly dosing, with a half-life of approximately five days, meaning the medication remains active in your body for an extended period