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very interesting Once your liver stores have been repleted, cells have adequate B12 and the transport mechanisms have been saturated, there is nowhere else for the B12 to go but into urine

Indications include: Medically refractory disease not responding to optimized biologic therapy Bowel obstruction from fibrostenotic stricture Intra-abdominal abscess not amenable to percutaneous drainage Complex perianal fistula (seton placement, diversion) Enterocutaneous or enterovesical fistula Dysplasia or cancer in Crohns colitis Free perforation (rare) Nutritional Therapy Exclusive enteral nutrition (EEN) effective for induction in pediatric Crohns

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High-dose methionine (above 100 mg per injection) can elevate homocysteine levels in susceptible individuals, increasing cardiovascular risk if used long-term without folate co-supplementation

While more expensive than some supplements, many users find the metabolic benefits justify the investment

PMID 25117994