10,11,15 Aging skin displays fragmentation of collagen and elastin fibers by the action of matrix metalloproteinase (MMPs), and increased mitochondrial oxidative stress results in deletions of mitochondrial DNA via the c-Jun/AP-1 pathway in dermal fibroblasts (Figure 1)
Factors like stress, poor diet, environmental toxins, and UV exposure can further deplete these levels, leading to signs of aging such as dull skin, brittle nails, and thinning hair
Fadia BS, Mokhtari-Soulimane N, Meriem B, Wacila N, Zouleykha B, Karima R et al (2022) Histological injury to rat brain, liver, and kidneys by gold nanoparticles is dose-dependent
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