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The significance of this reaction is that the level of 2MBC increases in the context of defects in isoleucine catabolism, particularly isoleucine degradation, particularly short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency
Wagner, U., Edwards, R., Dixon, D
It is frequently used in anti-aging contexts to reduce age spots and improve skin elasticity
However, it is important to note that results from animal experiments may not directly apply to humans
Mitochondrial oxidative stress causes hyperphosphorylation of tau
Proc Natl Acad Sci USA 99(16):10831
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