In patients with type 2 diabetes, the mean population-PK estimated steady-state concentrations following once weekly subcutaneous administration of 0.5 mg and 1 mg semaglutide were approximately 65.0 ng/mL and 123.0 ng/mL, respectively
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[8] The peptide reportedly elevated VEGFA, angiopoietin-2, and Tie2 receptor expression in these models, with researchers proposing this may occur through a Notch-to-NF-B signaling axis in experimental settings