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These findings highlight the need for prospective studies that integrate longitudinal assessments of weight, thyroid function, and levothyroxine dosing to validate these results and clarify the mechanisms linking GLP-1RA use to cardiovascular outcomes, including atrial fibrillation/flutter and stroke

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It suggests that the immune responses generated are generally low-titer and do not interfere with the drug's ability to engage its receptors and elicit a therapeutic effect in vivo

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In addition, the analysis considered patients previous medical interventions, including a history of bariatric surgery and prescriptions for antidepressants, antidiabetic medications, and other relevant therapies