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The oral-contraceptive interaction is a separate study (GPGR), reported in the FDA Mounjaro NDA 215866 summary review: a single 5 mg tirzepatide dose with a combination oral contraceptive (0.035 mg ethinyl estradiol / 0.25 mg norgestimate) reduced the Cmax of norelgestromin and ethinyl estradiol by 55% to 59% a range spanning both analytes, not a separate figure for each with AUC lowered 28.8% (norelgestromin) and 27% (ethinyl estradiol), and tmax delayed 2.5 to 4.5 hours

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Reading is reported in EU/mg of peptide on the Certificate of Analysis at cell-culture-reference acceptance limits, which supports use of Tesamorelin in pituitary somatotroph cell models, GHRH receptor binding assays, and other workflows where LPS-driven confounding signals would otherwise compromise the readout

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