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Accordingly, acute administration of exendin-4 (but not GLP-1) into the ARC potently reduces food intake [128], while liraglutide directly activates ARC POMC neurons [126, 155] and its weight-lowering effects upon chronic systemic administration are partially prevented when exendin-9 is co-administered into the ARC [126]
Verkhratsky, A., Marutle, A., Rodriguez-Arellano, J
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Anveden, et al
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