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Its most cited proposed mechanism is an increase in brain-derived neurotrophic factor (BDNF) and its receptor TrkB, alongside modulation of monoaminergic systems (dopamine, serotonin) and the melanocortin pathway [3] [4]
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Potential for Combination with NAD+ Augmentation : Since both NAD+ and 5-Amino-1MQ act on related pathways, their synergistic potential has become a growing topic in experimental design
(b-d) Representative subsets of mice from Fig
Zhang, R., Xu, L., and Dong, C., Protein Peptide Lett
Additionally, some researchers have raised concerns with long term cyanocobalamin supplementation, due to the cyanide present in the compound (18)
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