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PCE counteracted the impact of CYP on the detrusor muscle (ROCK1, VAChT) while urinary BDNF/NGF alterations alleviated DO in cystometry

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By combining all three receptor targets, Retatrutide allows researchers to study the convergence of incretin biology and glucagon-driven energy expenditure in a single compound, opening research questions that cannot be addressed with any dual or single-receptor agonist