GLP-1 receptor agonists stimulate insulin release from the pancreas only when blood glucose is elevated, suppress glucagon (which reduces liver glucose production), and slow gastric emptying to moderate glucose absorption after meals
(2025) Disproportionality analysis of GLP-1 receptor agonists combined with metformin based on the FAERS database.Sci Rep 15, 2.Xie Z, Hu J, Gu H, Li M and Chen J (2023) Comparison of the efficacy and safety of 10 glucagon-like peptide-1 receptor agonists as add-on to metformin in patients with type 2 diabetes: a systematic review.Front
In SURMOUNT-1, tirzepatide reached around 22.5% mean body-weight reduction at the top end
Should I change my schedule
For Wegovy, the initial dose is 0.25 mg per week, with gradual increases every 4 weeks until reaching a maintenance dose of 2.4 mg
10.1186/s12866-015-0462-0 23 Casado-VelaJ.SellsS.MartnezR