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3.2 Adipose tissue In humans, infusions of GIP(3-30)NH 2 during a hyperinsulinemic and hyperglycemic clamp reduce GIP-induced blood flow to subcutaneous adipose tissue and inhibit the increase in triacylglycerol clearance observed with GIP administration (22)

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Our observation of only a tendency for reduced -arrestin 2 recruitment at the phospho-null mutant receptor is also in agreement with a previous report highlight the biphasic mode of -arrestin 2 GLP-1R interaction, with a phosphorylation-independent as well as a phosphorylation-dependent component (28)

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By analyzing the reported adverse events in the US Food and Drug Administrations database, Elashoff reported that treatment with DPP4 inhibitor sitagliptin or GLP-1R agonist exenatide increased the risk of pancreatitis and pancreatic cancer as compared with other therapies

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