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For example, a new structurefunction relationship was used to prepare a pH-sensitive cationic lipid nanoparticle with a suitable combination of hydrophilic head groups and hydrophobic tails, which could promote liver cell targeting and endosome escape and affect the use of siRNA [97]

Souza L, Lima AA

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215 Although both ER-alpha and ER-beta are important for ovarian development and function and cardiovascular protection, ER-alpha is the more prominent mediator of estrogens effects on metabolism and the breasts, uterus, and bones, whereas ER-beta is more involved in mediating nervous system and immune effects of estrogen, and counteracts pro-proliferation signaling by ER-alpha in the breasts and uterus

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f-j , Volcano plot of metabolic differences ( f) and levels of GSSG (g) , ophthalmic acid (h) , glutamate (i) , cysteine (NEM-cysteine) (j) from Gclc WT and Gclc KO tumors