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However, the SUSTAIN six trial evaluated semaglutide, a GLP-1 analog, in patients with type 2 diabetes and high cardiovascular risk and discovered that semaglutide was associated with a higher incidence of diabetic retinopathy complications compared to placebo, with a hazard ratio (HR) of 1.76, particularly in patients with pre-existing DR ( This seemingly controversial impact of GLP-1RAs on DR may be because most trials focused on microvascular and cardiovascular outcomes rather than DR

At Slinic, our safety-first approach includes: Regular video consultations to assess your response to the titration schedule

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These multifactorial benefits are particularly valuable considering the close association between T2DM and dyslipidemia, where managing both glycemic control and lipid metabolism plays a critical role in reducing cardiovascular risk (146)

Insulin signaling at the islet (retatrutide GIP) muscle glucose uptake (MOTS-c)

PMID 25554787