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Abbreviations PWS: PraderWilli syndrome IR: Insulin resistance IS: Insulin sensitivity BMI: Body mass index T2DM: Type 2 diabetes mellitus HOMA-IR: HOMA IR index NAFLD: Non-alcoholic fatty liver disease PBF: Percent body fat AT: Adipose tissue VAT: Visceral adipose tissue SAT: Subcutaneous adipose tissue TNF-: Tumor necrosis factor- HMW: High molecular weight gAd Tg: Globular domain adiponectin transgenic AG: Acyl ghrelin DAG: Desacyl ghrelin OXT: Oxytocin Oxtr / : OXT receptor-deficient GH: Growth hormone GHD: Growth hormone deficiency IGHD: Isolated growth hormone deficiency GHKO: Growth hormone knockout GHRKO: Growth hormone receptor knockout ANS: Autonomic nervous system References Tauber M, Hoybye C

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-MSH is produced in the pituitary gland and is involved in various physiological processes, including skin tanning, energy homeostasis, and the suppression of inflammation

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