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The neuroprotective effect of rhGLP-1 might be based on promoting expression of the phase II detoxification enzyme HO-1, activating PI3K to up-regulate expression of antioxidant enzyme SOD, and nuclear transfer of Nrf2 proteins

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Sikiric's group documented this in tendon fibroblast cultures

Furthermore, in rat models, the GLP-1 RA exendin-4 was found to alleviate ischemiareperfusion injury in skin flaps by upregulating Gpx4 expression, thereby inhibiting ferroptosis [73]

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