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In a series of papers [3436], Ookhtens and colleagues showed that the half-life of glutathione in the liver was quite low, approximately 23 hours, consistent with the result of Lauterburg [47]

But more physiologic does not mean no oversight needed. It still warrants a clear rationale, appropriate bloodwork, and monitoring over time

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples

The secondary end points included change in body weight and safety

If you or someone you love is struggling with alcohol use and also meets criteria for a GLP-1 prescription (typically type 2 diabetes or a BMI over 30), its worth having a conversation with a healthcare provider about whether these medications might serve a dual purpose

Wit JG (1968)