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GIP -CNS, GIP , Purkinje -olfactory bulb ( Nyberg ' -J Neurosci Res 2007)

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These tradeoffs are not merely theoretical: in the pilot phase of the PRECIDENTD pragmatic trial, participants assigned to dual therapy had substantially lower medication fill rates and higher discontinuation than those on monotherapy, driven largely by side effects, cost, and access [36]

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Why Loose Skin Happens After Weight Loss When we gain weight, the skin stretches to accommodate increased fat tissue