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Understanding the Retatrutide starting dose: A research-based guide The retatrutide starting dose used in clinical trials was 1 mg and 2 mg once weekly, a carefully chosen amount to balance powerful efficacy with patient safety

Importantly, these medications carry boxed warnings for medullary thyroid carcinoma risk and are contraindicated in patients with personal or family history of MEN2 or medullary thyroid carcinoma

In the SURMOUNT-5 trial, participants treated with Zepbound achieved an average weight reduction of 20.2% compared to 13.7% with Wegovy at 72 weeks

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