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10.1172/JCI78371 13 CabouC.BurcelinR
The chemistry behind the once-weekly half-life The lipid-modification strategy is the same one used for tirzepatide and semaglutide: a long-chain fatty diacid attached to a lysine side chain via a small linker, producing a molecule that binds reversibly to serum albumin and clears far more slowly than an unmodified peptide would
It is a useful reminder that stimulating endogenous GH is not automatically equivalent to, or stronger than, giving GH directly and that the peptides documented effect sizes are modest even in the population where it was best studied
Cancer outcomes, mental health effects, and quality of life measures all factor into comprehensive evaluation of therapeutic value beyond scale weight changes
Nature Medicine, 28(10), 2083-2091
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