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Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use semaglutide
The effect strengthens with each dose escalation, with maximum appetite control typically reached at the 2.4mg maintenance dose around week 17
Other GLP-1 receptor agonists are available, including injectable formulations such as liraglutide (Victoza), dulaglutide (Trulicity), and once-weekly semaglutide (Ozempic)
In a phase 2B study of lanifibranor, the percentage of patients who achieved at least a two-point reduction in the SAF-A score without fibrosis progression was significantly higher among those receiving the 1,200-mg dose compared to placebo (1,200-mg dose vs