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Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Mura et al., 2013

respectively)

PLoS Biol 13(4):e1002126 Lenard A et al (2013) In vivo analysis reveals a highly stereotypic morphogenetic pathway of vascular anastomosis

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