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Several healthcare reform proposals culminated in the enactment of the Inflation Reduction Act (IRA) in August 2022, which will eliminate, beginning in 2025, the coverage gap under Medicare Part D by significantly lowering the enrollee maximum out-of-pocket cost and requiring manufacturers to subsidize, through a newly established manufacturer discount program, 10% of Part D enrollees prescription costs for brand drugs below the out-of-pocket maximum, and 20% once the out-of-pocket maximum has been reached

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(5) This elevation in calcium is thought to play a role in neuronal excitability and synaptic modulation, affecting the transmission of signals across neurons

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