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In recent years, we added an epigenetic component to the Allostasis/Allostatic load model to describe how non-shared environmental experiences may set each individual on a somewhat different trajectory of development that determines either adaptive or maladaptive responses (behavior, systemic function and vulnerability to disease) to subsequent novel experiences as the life course unfolds [20]

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These Supra-LYTACs co-assemble with target proteins to form dynamic ternary complexes that are selectively internalized into CAIX-expressing tumor cells, where multivalent engagement accelerates lysosomal degradation of the captured protein [72]

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The effects of heroin on GABAergic interneurons in the ventral tegmental area enhance dopamine release in the nucleus accumbens (Kim et al., 2015), producing euphoria (Saurer et al., 2009)

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