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Use during pregnancy and lactation should be limited to cases where the benefits outweigh the risks, as high-dose parenteral administration has not been fully studied in these populations

Either approach works as long as the math is consistent

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The severe infantile multisystem form manifests in the first 624 months of life with most afflicted infants demonstrating significant involvement before 1 year

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Self-reported community timelines describe headache and (less commonly) chest pressure within 1-4 hours of higher doses