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Tirzepatide is a GIP and GLP-1 receptor agonist, meaning it activates two gut-hormone receptor pathways involved in glucose regulation and appetite

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In the liver, the 25-hydroxylase enzymes (CYP2R1 and CYP27A1) convert inactive cholecalciferol to 25(OH)VD 3 (calcidiol) by carbon 25 hydroxylation 14

Oral supplements can be helpful, but theyre not as efficient as injections