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Statistics and reproducibility Statistical significance was determined using independent t -test for immunohistochemical and western blot analyses, and one-way analysis of variance for cell cycle and apoptosis detection by GraphPad Prism 7.0 software (GraphPad, Inc., La Jolla, CA, USA)

This is not a controlled human dose-ranging trial

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These include temporary skin redness, itch, or irritation after topical application, reported in a small percent of users, single-digit percentages in trials

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