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Biochemical journal, 255(1), 153-159

In animal studies, it has been associated with upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) and activation of the nitric oxide (NO) pathway, both of which support the growth of new blood vessels into injured tissue

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For researchers just starting their retatrutide dose escalation at 1-2mg weekly, this margin of error can be significant