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In the late 1970s, it was first shown that an APAP overdose triggered massive LPO in the liver, measured by ethane and pentane exhalation, and severe liver injury with high mortality in a murine model [11]

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However, further research studies reported that glutathione supplements taken for this purpose lead to problems that may include allergic reactions with itchy and irritated skin, fatigue, and erythema-producing redness spots on the skin