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In some cases, physical therapy, pain management, or even surgical intervention may be required to address long-term complications

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doi: 10.1186/s12955-019-1165-2 6 BouhanickB.CracowskiJ.FaillieJ.French Society of Pharmacology, Therapeutics (SFPT) (2020)

Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function