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Many professionals recommend weekly sessions initially, followed by maintenance doses based on desired results

However, certain circumstances may warrant testing including pre-existing liver or kidney conditions where monitoring organ function during therapy provides appropriate oversight, specific health concerns that might benefit from objective biomarker assessment, desire to objectively measure oxidative stress markers or glutathione status before and during therapy, and medical conditions requiring monitoring for safety reasons

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Baar et al

Key indicators include increased retinal vascular permeability, infiltration of inflammatory cells, and expression of inflammatory and chemotactic factors, ultimately leading to retinal tissue deterioration, capillary degeneration, and neovascularization [150]