The presence of GLP-1 receptors in brain regions central to reward processing (Lpez-Ojeda & Hurley, 2024), together with evidence that GLP-1 RAs can modulate activity within these circuits (Gabery et al., 2020), has led to the hypothesis that GLP-1 RAs may reduce vulnerability to multiple maladaptive reward-seeking behaviors by blunting neuroaffective responses to reward-related cues (Eren-Yazicioglu et al., 2021
L-citrulline demonstrates superior bioavailability compared to l-arginine due to bypassing hepatic first-pass metabolism
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Appl Microbiol Biotechnol 99(13):53735382 Lazard M, Dauplais M, Blanquet S, Plateau P (2017) Recent advances in the mechanism of selenoamino acids toxicity in eukaryotic cells
This allows for precise dosing adjustments
The Wegovy SmPC and the MHRAs public guidance are aligned on this point: semaglutide shouldnt be used during breastfeeding, because a risk to a breastfed child cannot be excluded
