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7.2.1 Prodrug Design SAG adopts advanced prodrug technology, a mature approach widely used in the pharmaceutical industry

1- Free GSH=DTNB+Sample+Substrate 2- Total GSH=DTNB+Sample+Substrate+ NADPH+glutathione reductase 3- GSSG=Total GSH-Free GSH Another method to measure GSSG separately, is to remove the free GSH from DTNB reaction process by modification of free GSH with N-ethylmaleimide (NEM) or vinylpyridine prior to conducting assay

A big challenge is patient heterogeneity age, baseline cognitive reserve, etc

GLOBAL GLUTATHIONE MARKET SIZE, BY IV INFUSIONS, BY GROUP, 2018-2032 (USD MILLION) TABLE 138

Baseline aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin before starting IV glutathione, with a repeat panel at 8 to 12 weeks, is a reasonable precaution

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