The medication primarily addresses homeostatic hunger (eating for energy needs) but may have variable effects on hedonic hunger (eating for pleasure), though this conceptual framework requires further clinical validation
For Wegovy (2.4 mg), nausea affects approximately 44% of patients, with diarrhea (30%), vomiting (24%), and constipation (24%) also commonly reported
Individuals typically start experiencing weight loss within the first few weeks of the program, with continued progress over time
Most people are surprised by how minimal the discomfort is
This albumin binding also explains why tirzepatide clearance is remarkably slow
According to FDA prescribing information, these include nausea, vomiting, diarrhea, constipation, and abdominal pain