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CRC, colorectal cancer

Under low oxygen conditions, HIF-1 acts as a key modulator of mitochondrial metabolism, actively repressing oxidative phosphorylation (OXPHOS) to reduce cellular oxygen consumption and mitochondrial-generated reactive oxygen species (ROS), which can be toxic at high levels (78)

If GH-related effects such as improved sleep quality, recovery speed, or body composition changes plateau before the cycle ends, that is an early signal of receptor saturation

Tian et al., 2019)

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High- and low-molecular weight oat beta-glucan reveals antitumor activity in human epithelial lung cancer