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Thus, using complementary pharmacological and chemogenetic approaches, we provide evidence that the modulation of GLP-1 signalling in the OB contributes to the maintenance of energy homeostasis, and that augmenting OB GLP-1 signalling can improve metabolic parameters deregulated in the context of obesity

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If significant insulin sensitivity changes occur despite healthy lifestyle, dose reduction or cycling becomes necessary

So let's just say that like the starting dose of your GLP one will depend on which one you're actually using

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