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While LBM loss appears to be less pronounced than FBM loss in many studies, the clinical significance of even modest reductions in skeletal muscle remains uncertain, particularly in older adults or individuals at risk of sarcopenia

Combined with reduced food intake, this creates conditions for constipation

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We observed no effect measure modification after stratifying patients by history of renal disease (supplementary table M)

Seek immediate medical care (emergency department or urgent care) if you experience: Severe, persistent abdominal pain, especially in the right upper quadrant, lasting more than a few hours Abdominal pain accompanied by fever (temperature above 100.4F or 38C) Yellowing of the skin or eyes (jaundice) Severe nausea and vomiting preventing fluid intake and leading to dehydration Dark urine combined with pale stools Abdominal pain radiating to the back, which could indicate pancreatitis The combination of fever, jaundice, and abdominal pain, which may indicate cholangitis (bile duct infection) Confusion, extreme weakness, or very low blood pressure with any of the above symptoms (possible signs of sepsis) Important: If you experience severe, persistent abdominal pain with or without vomiting that could be consistent with pancreatitis, stop taking semaglutide immediately and seek urgent medical care, as directed in the FDA labeling

But the real-world concerns I hear every day are not hard to predict: How long do I have to stay on this? What happens if I stop? Will insurance keep paying? Can I afford this for years? Is there a better long-term alternative? Those are smart questions