Other considerations when taking melatonin include (EMA, 2012): Cigarette smoking may reduce melatonin levels, possibly making melatonin supplements less effective
GNAQ or GNA11 mutations are typically associated with blue nevi
Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ
A neutrophil elastase inhibitor reduces cigarette smoke-induced remodelling of lung vessels
Even though lower doses are presumably safer, using them would still require a new pre-IND safety justification, dose-range toxicology studies, and possibly a new manufacturing lot release. That would add ~12 years of delay
If your reading is below 4 mmol/L, follow your diabetes management plan for treating low blood sugar